Home > sacroiliac joint treatment > prolotherapy


Treatment Overview
Physical Therapy
SI Joint Injection
Surgical Intervention
SI Joint Fusion
iFuse Implant System
Causes for Sacroiliac Joint Injury
Sacroiliac Joint Arthritis
Sciatica and the Sacroiliac Joint: A Forgotten Concept
Questions & Answers With Dr. Amish Patel
Low Back Pain's Missing Piece
Sacroiliac Joint Fusion

Sacroiliac Joint Prolotherapy

Prolotherapy, also known as “proliferation therapy”, is the injection of an osmotic or chemical irritant into a tendon or ligament in order to produce an inflammatory response within the injured tissue. The inflammatory response stimulates production of connective tissue and release of growth factors within the injected site for the desired effect of strengthening the target tissue, and thereby relieving musculoskeletal pain.

The majority of randomized controlled trials on the use of prolotherapy have been for nonspecific chronic low back pain; prolotherapy for the sacroiliac joint has not been well researched. One study on 19 patients who had previously experienced significant but temporary pain relief after intra-articular sacroiliac joint injections found positive responses in 79%, 63%, and 58% at 3, 6, and 12 months, respectively.9

A 2010 randomized controlled trial of intra-articular prolotherapy vs. sacroiliac joint steroid injection found a cumulative incidence of ≥50% pain relief at 15 months in 58.7% of the prolotherapy group vs. 10.2% of the steroid injection group.10

In a prospective cohort study on 25 patients, 76% of the patients seen for follow up at 12 months had a positive clinical outcome, which decreased to 32% at 24 months.11

Next page: Sacroiliac Joint Surgical Intervention

Learn more:
Sacroiliac Joint Anatomy
Sacroiliac Joint Treatment Options
Watch: Low Back Pain's Missing Piece


  1. Chakraverty R, Dias R. Audit of conservative management of chronic low back pain in a secondary care setting – Part I: facet joint and sacroiliac joint interventions. Acupuncture in Medicine 2004;22(4):207-213.

  2. Kim WM et al. A randomized controlled trial of intra-articular prolotherapy vs. steroid injection of sacroiliac joint pain. J Altern Complement Med 2010. Dec;16(12):1285-90.

  3. Cusi M et al. The use of prolotherapy in the sacroiliac joint. British J Sports Med 2010. Feb;44(2):100-4.








Button 1

Button 2

Button 3

Si-bone.com| About Us | Privacy Policy | Terms of Use | Contact Us | Sitemap